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This bacterial defence mechanism has been shown to promote an anti-inflammatory response and induce a disease-tolerant immune response ( Psuedomonas aeruginosa and Staphylococcus aureus utilise itaconate as a carbon source to establish a persistent infection and support the development of biofilms ( Figure 1B )

Similarly, drugs from the class of aromatase inhibitors (AIs), including letrozole, anastrozole, and exemestane, have also shown positive results in postmenopausal women (214)